REVEAL(R) RegistryData May Advance Patient Care in Pulmonary Arterial Hypertension

Mon, 05/17/2010 - 10:37am

NEW ORLEANS, May 17 /PRNewswire-FirstCall/ -- Actelion Ltd (SIX: ATLN) announced today that findings from the REVEAL® (Registry to EValuate Early And Long-term PAH Disease Management) Registry have confirmed the clinical utility of the REVEAL risk score calculator, a new tool designed to predict 1-year survival in patients with pulmonary arterial hypertension (PAH) according to data presented at the American Thoracic Society's (ATS) Annual International Conference. The predictive tool was developed and validated in patients enrolled in REVEAL, the largest prospective registry in PAH containing data from more than 3,500 patients.  

"The REVEAL risk score calculator provides an innovative approach to better understand pulmonary arterial hypertension by looking at a unique combination of variables, that together, can help predict patient survival," said Raymond L. Benza, M.D., Medical Director of the Gerald McGinnis Cardiovascular of Advanced Heart Failure, Transplantation, Mechanical Circulatory Support and Pulmonary Hypertension Program, and Director of the Gerald McGinnis Cardiovascular Institute Center for Research and Innovation at Allegheny General Hospital, Pittsburgh.  "We look forward to obtaining more data from the REVEAL Registry that can be used as an adjunct to the clinical experience and judgment of physicians who treat this chronic and life-threatening disease."

About "Use of REVEAL PAH Risk Score Calculator in Newly Diagnosed Patients"

Data from 2,717 newly and previously diagnosed PAH patients enrolled in REVEAL were used to develop a predictive tool from a stepwise model based on nineteen variables, including WHO Group I subgroup, mean right atrial pressure, pulmonary vascular resistance




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