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BSGI Offers Improved Cancer Detection for Negative or Indeterminate Mammograms

Thu, 06/03/2010 - 5:38am
Bio-Medicine.Org

NEWPORT NEWS, Va., June 3 /PRNewswire/ -- Researchers at the Legacy Good Samaritan Hospital in Portland, Oregon presented data on the clinical use of Breast-Specific Gamma Imaging (BSGI), a molecular breast imaging technique, at the American Society of Breast Surgeons Annual meeting in Las Vegas in April: Breast Specific Gamma Imaging Used As An Adjunct to Mammography.  

664 patients were involved in the retrospective review where BSGI was evaluated as part of the diagnostic work-up of patients that had presented with abnormal mammographic or ultrasound imaging, physical exam, significant family or personal breast cancer history or dense breasts. Overall, the sensitivity was 85 percent with a specificity of 81 percent. The positive predictive value (PPV) was 68 percent and the negative predictive value was 81 percent. Using the Breast Imaging Reporting and Data System (BI-RADS), the PPV for BI-RADS 1-3 of 30% compares favorably with the expected BI-RADS prediction of <2 percent malignancy rate for this category. In the BI-RADS 4-6 group, the PPV increased considerably to 86%.

Dr. Nathalie Johnson, Medical Director of Cancer Services at Legacy Good Samaritan Hospital, and principal investigator on the study, concluded, "BSGI is a useful adjunct in the imaging work-up of breast patients and has a high sensitivity and specificity. It is best used to further evaluate unclear mammographic or ultrasound findings, as the positive predictive value is highest in this setting. However, in high-risk patients with BI-RADS 1-3, it will improve cancer detection significantly."

Overall, mammography and BSGI were both positive in 144 cancers. BSGI was positive in 23 cancers which were negative by mammogra

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