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Cardinal Health Supports ACRIN Clinical Trials Evaluating Oncologic Biotracers

Thu, 06/03/2010 - 7:37am
Bio-Medicine.Org

DUBLIN, Ohio, June 3 /PRNewswire-FirstCall/ -- Researchers have long used non-proprietary imaging agents such as 18F-Fluoroumisonidazole (FMISO), 18F-Sodium Fluoride and Fluorothymidine (FLT-PET) to evaluate cancerous tumors. Now, with manufacturing and distribution support from Cardinal Health, the American College of Radiology Imaging Network (ACRIN) is conducting nationwide clinical trials with positron emission tomography (PET) to determine if these agents can be used in new ways to assess the efficacy of cancer treatments.

The ACRIN trials, funded by the National Cancer Institute, aim to better characterize cancerous tumors and to help oncologists select the most appropriate treatment for patients with cancer. The research also aims to help develop strategies to more quickly evaluate new cancer treatments and speed the delivery of effective drugs into clinical use.  

The four ACRIN clinical trials that Cardinal Health is supporting include:

  • A clinical trial to determine whether FMISO can be used as a biotracer to measure the oxygen level (or hypoxia) of a specific type of brain tumor called glioblastoma. Knowing how hypoxic a tumor is may help treating physicians determine the best course of therapy for their patients. Cardinal Health is the only entity to have a drug master file with the Food and Drug Administration (FDA) to produce this imaging agent.

  • A clinical trial to determine whether 18F-Sodium Fluoride, a bone imaging agent, can be used to gain information about how the drug dasatinib may work in treating castration-resistant prostate cancer that has spread to the bone.

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