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Hebrew University-developed method for control of malaria applied in Africa

Mon, 11/08/2010 - 8:39am
EurekAlert

This is an Anopheles gambiae mosquito on a leaf with colored drops of ATSB, the toxic material that has been shown to be effective in eliminating these mosquitoes.

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Jerusalem, November 8, 2010 Research carried out in Mali, West Africa, has demonstrated that a new, safe and uncomplicated insect control method, developed at the Hebrew University of Jerusalem, can bring about a serious decline in malaria-bearing mosquitoes in afflicted regions in the world.

The research in Africa was based on work carried out earlier in Israel by researchers at the Kuvin Center for the Study of Tropical and Infectious Diseases at the Hebrew University of Jerusalem that showed how attractants of plant origin (fruit or flowers) with a toxic sugar bait can reduce the populations of the malaria-transmitting mosquitoes.

Their work is detailed in a recent issue of the Malaria Journal. The scientists involved in the project are Prof. Yosef Schlein and Dr. Gunter C . Muller of the Kuvin Center and the Institute for Medical Research Israel-Canada (IMRIC), Prof. John C. Beier of the University of Miami, Florida, and Prof. Sekou F. Traore, Prof. Seydou Doumbia, Dr. Mahamadou B. Toure, Dr. Mohamed B. Traore and Dr. Sekou Bah, all of the University of Bamako, Mali.

Their work in the use of the Hebrew University-developed Attractive Toxic Sugar Bait Method (ATSB) was applied to control malaria-bearing mosquitoes in the semi-arid Bandiagara District of Mali, West Africa.

Control and treatment sites were selected along a road that connects villages and that had man-made ponds that were the primary larval habitats of Anopheles gambiae and Anopheles arabiensis mosquitoes. Guava and honey melons, two local fruits that have been found to be attractive to both species of mosquitoes, were used to prepare solutions of Attractive Sugar Bait (ASB) and ATSB, the latter containing an additive of boric acid as an oral insecticide. Both included a color dye marker to facilitate determination of mosquitoes feeding on the solutions.

ASB solution in the control site and ATSB solution in the treatment site were sprayed on patches of the vegetation. Consequently, it was seen that the relative abundance of female and male mosquitoes in the ATSB-treated site declined dramatically by about 90% and remained low during one month of monitoring. The females in the diminished population were mostly too young to transmit malaria. In parallel, dye marking in the solutions sprayed in the control site provided evidence that most of the mosquitoes were feeding on the sprayed solutions.

The researchers concluded that the study in Mali shows that even a single application of ATSB can substantially decrease malaria-bearing mosquito population densities and longevity. It is thus likely that ATSB methods can be used as a new, powerful tool for the control of malaria insect carriers, since this approach is highly effective for mosquito control, technologically simple, inexpensive and environmentally safe.

The work in Mali is very much connected to Bill and Melinda Gates Foundation funding of early studies, and this initial report can set the stage for bigger efforts in African countries. It is one of the first new dimensions to control African malaria vectors, yielding good indications that use of ATSB in outdoor environments will complement the current measures to control mosquitoes inside houses.

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