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Announcement - Clontech Laboratories, Inc. Releases the Tet-Expressâ„¢ Inducible Expression System

Thu, 02/17/2011 - 4:34am
Bio-Medicine.Org

MOUNTAIN VIEW, Calif., Feb. 17, 2011 /PRNewswire/ -- Clontech Laboratories, Inc., a wholly-owned subsidiary of Takara Bio Inc., today announced the release of the Tet-Express Inducible Expression System, which provides the quickest and simplest Tet-inducible expression technology yet. At the heart of this new system is a cell membrane-permeable version of Clontech's Tet-Off® Advanced transcriptional activator protein (the Tet-Express transactivator) that can enter cells directly, i.e., without transfection. The Tet-Express system eliminates the requirement for a double-stable cell line expressing both the gene of interest and the tetracycline transactivator. Instead, only the gene of interest is cloned into the cells; then when gene expression is required, simply add the self-transducing Tet-Express protein directly to the cells in order to turn on the gene of interest. Since the Tet-Express protein binds and activates expression in the absence of tetracyclines, doxycycline is not required for gene activation, further simplifying the system. Clontech has filed for patent protection for the Tet-Express system.

Carol Lou, General Manager of Clontech Laboratories, Inc., comments: "Clontech has a long history of leadership in developing technologies for gene delivery and expression. We are pleased to continue and extend this history by adding the Tet-Express Inducible Expression System to our portfolio of Tet System Products, which are the gold standard for regulated gene expression."

For maximal expression and minimal background, the Tet-Express Inducible Expression System contains Clontech's latest and tightest Tet System promoter, TRE3G, which is found in Clontech's Tet-On® 3G Expression Systems (developed and marketed under a license from TET Systems GmbH and Co. KG)

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