Cytotech Labs Unravels Hallmark Insight Into Metabolic Control of Cancer, Presents Work at Major AACR Cancer Meeting
ORLANDO, Fla., April 4, 2011 /PRNewswire/ -- Cytotech Labs, a Boston based pharmaceutical company and member of the Berg Pharma, Inc. group along with Berg Biosystems and Berg Diagnostics today presented groundbreaking insight into seminal work performed by Nobel Laureate, Otto Warburg. The Warburg Hypothesis asserts that increased utilization of anaerobic respiration and production of lactate is negotiated by cancer cells in return for evasion of apoptosis, programmed cell death and other key characteristics of a healthy cell such as normally functioning mitochondria, the cell's energy and metabolic headquarters. This area of research has become of intense importance to medical research in the past decade for many disease states.
The use of the Berg Biosystems Interrogative Biology™ discovery platform was a vital asset in enabling the biological intelligence necessary to demonstrate that the molecule ubidecarenone, a coenzyme that shuttles electrons though mitochondria was depleted in cancer cells but strikingly created a shift from dependency of lactate production to create a "breach of contract" between the cancer cell and its preferred metabolic environment. Dr. Ralph Weichselbaum, D.K. Ludwig Professor and Chairman of Radiation and Cellular Oncology at the University of Chicago Pritzker School of Medicine commented, "I have been very intrigued and highly impressed with Cytotech's innovation and overall approach using the Berg systems biology platform to develop a whole a new avenue of therapeutic drug discovery."
Original discoverer, Niven R. Narain, now President and CTO of Berg Biosystems in Boston, founding CTO of Cytotech Labs, and former Director of Cutaneous Oncology Research at the University of Miami Miller School of Medicine, where the seminal research on cancer began stated, "It is humbling to carry o