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Inovio Pharmaceuticals Demonstrates Positive Immune Responses in Phase I Clinical Trial of SynConâ„¢ H5N1 Influenza Vaccine and Launches Multi-Subtype Influenza Vaccine Phase I

Thu, 07/14/2011 - 2:36am
Bio-Medicine.Org

BLUE BELL, Pa., July 14, 2011 /PRNewswire/ -- Inovio Pharmaceuticals, Inc. (NYSE Amex: INO), a leader in the development of therapeutic and preventive vaccines against cancers and infectious diseases, announced today that significant T cell and antibody responses were generated in its Phase I clinical study of VGX-3400X, a SynCon™ DNA vaccine for the prevention of avian H5N1 influenza delivered using intramuscular (IM) electroporation. These results were presented at DNA Vaccines 2011, hosted in San Diego by the International Society of DNA Vaccines, by Dr. Niranjan Sardesai, Inovio's Sr. VP, Research and Development. In conjunction with these results, Inovio has launched a second Phase I clinical study as part of its universal influenza vaccine program. This trial will assess a multi-subtype SynCon vaccine for H1N1 and H5N1 influenza using its skin-targeted intradermal (ID) electroporator. Inovio's SynCon™ vaccine design process uses a proprietary method to achieve cross-strain protection against the natural and frequent mutations of influenza strains within subtypes.

Dr. J. Joseph Kim, Inovio's president and CEO, said: "We are encouraged by the immune responses generated in this proof-of-principle study of our first SynCon™ influenza vaccine, VGX-3400X, delivered using intramuscular electroporation. The second Phase I study (INO-3510) builds on our universal influenza vaccine development program by adding a second component targeting the H1N1 subtype and delivering vaccine formulations using our minimally invasive intradermal electroporation delivery system, which is designed to directly access the skin tissue that is most ideal for inducing preventive antibody responses. Inovio's ultimate goal is to develop a broadly cross-protective influenza vaccine simultaneously targeting multiple flu sub-types and unmatched strains within subtypes. We are approaching

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