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Study supports fixing heart valves without surgery

April 3, 2011 5:45 am | by MARILYNN MARCHIONE - AP Medical Writer - Associated Press | Comments

Many people with a bad aortic valve may soon be able to avoid open-heart surgery and have a new one placed through a tube in an artery instead.A study finds that survival after a year is about the same for either way of replacing the aortic valve, which is the main gate for blood leaving the...

Young black athletes with sickle cell trait might be susceptible to sudden death

April 3, 2011 12:37 am | by EurekAlert | Comments

(Minneapolis Heart Institute Foundation) The sickle cell trait could be a cause -- albeit rare -- of sudden death in young African-American competitive athletes, most commonly during football training, according to a scientific poster that will be presented at the American College...

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Scientists Identify KRAS Rearrangements in Metastatic Prostate Cancer

April 2, 2011 9:31 pm | by AACR | Comments

Tweet • Genetic information may allow doctors to determine cancer prognosis. • KRAS is a known “oncogene” that leads to cancer. ORLANDO, Fla. - Scientists have uncovered a genetic characteristic of metastatic prostate cancer that defines a rare sub-type of this disease. These findings are...

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Digoxin May be a Possible Treatment for Prostate Cancer

April 2, 2011 9:31 pm | by AACR | Comments

Tweet • Digoxin has a long history as a treatment for heart failure. • New testing paradigm combined epidemiological and laboratory testing. • Repositioning existing therapies could speed drug approval time. ORLANDO, Fla. - Scientists have identified digoxin as a possible therapy for...

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New target identified for squamous cell lung cancer

April 2, 2011 8:34 pm | by EurekAlert | Comments

(American Association for Cancer Research) Scientists at the Dana Farber Cancer Institute have identified a mutation in the DDR2 gene that may indicate which patients with squamous cell lung cancer will respond to dasatinib.

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Chronic Stress of Cancer Causes Accelerated Telomere Shortening

April 2, 2011 12:35 pm | by AACR | Comments

Tweet • Telomere shortening is associated with deterioration of chromosomes. • Reducing chronic stress modulates telomere shortening. • Research presented during an AACR press conference. ORLANDO, Fla. - Results of a study presented at the AACR 102nd Annual Meeting 2011, held here April...

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Genetic Variation Linked to Longer Telomeres and Lower Risk of Bladder Cancer

April 2, 2011 12:34 pm | by AACR | Comments

Tweet • Telomere length tends to shorten with age and stress. • Interventions to lengthen telomeres key to cancer interception. • Research simultaneously published in Cancer Prevention Research. ORLANDO, Fla. - Using new genetic information, scientists have linked a commonly found human...

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Optimer Pharmaceuticals Announces Presentation at SHEA of Data Highlighting the Burden of Clostridium difficile Infection (CDI) in Hospital Patients

April 2, 2011 11:35 am | by Bio-Medicine.Org | Comments

SAN DIEGO, April 2, 2011 /- Optimer Pharmaceuticals, Inc. (NASDAQ: OPTR ) announced today the presentation of information from insurance claims and survey databases highlighting the unmet need for targeted therapies to treat subpopulations at high risk of recurrence of Clostridium...

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DNA of 50 Breast Cancer Patients Decoded

April 2, 2011 6:33 am | by AACR | Comments

Tweet • Reveals complexity and hints toward personalized medicine. • Patient tumors had more than 1,700 mutations. • Abstract to be presented during an AACR press conference. ORLANDO, Fla. - In one of the largest cancer genomics investigations reported to date, scientists have sequenced...

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Target for Lung Cancer Chemoprevention Identified

April 2, 2011 6:33 am | by AACR | Comments

Tweet • Endobronchial dysplasia can be modified pharmacologically. • Effect on endobronchial dysplasia was seen in former smokers. • Full study details to be presented at AACR press conference. ORLANDO, Fla. - Scientists have identified a biomarker for measuring the success of lung cancer...

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Combining MEK and PI3K Inhibitors Appears Encouraging in a Safety Study with Early Signs of Anti-tumor Activity

April 2, 2011 6:33 am | by AACR | Comments

Tweet • Combination therapy targets MEK and PI3K pathways. • Phase I trials of single agent MEK and PI3K pathway inhibitors alone have shown signs of anti-tumor activity. • Abstract to be presented at AACR press conference. ORLANDO, Fla. - The combination of two compounds that inhibit two...

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BATTLE Researchers Identify New Biomarkers for EGFR Inhibition

April 2, 2011 6:33 am | by AACR | Comments

Tweet • Protocol was one of the first to treat patients based on molecular profiling. • Two gene signatures were predictive of efficacy for erlotinib. • Updated results to be presented during AACR press conference. ORLANDO, Fla. - Scientists are continuing their work on the...

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New Inhibitor Prevented Lesions, Reduced Tumor Size in Basal Cell Cancer

April 2, 2011 6:32 am | by AACR | Comments

Tweet • Tumors decreased by 24 cm in patients who received GDC-0449. • No patients receiving GDC-0449 required surgery to remove tumors. • Data safety monitoring board stopped placebo arm at interim analysis. ORLANDO, Fla. - A new hedgehog pathway inhibitor demonstrated efficacy in...

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Data suggest liver experts should take care when prescribing novel antiviral HCV drugs

April 2, 2011 12:37 am | by EurekAlert | Comments

(European Association for the Study of the Liver) Data presented at the International Liver CongressTM highlight the fact that new novel antiviral compounds for the treatment of hepatitis C virus must be prescribed and monitored by experts and specialists to ensure resistance is minimized.

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New data show non-alcoholic fatty liver disease will reach epidemic status in the US

April 1, 2011 11:36 pm | by EurekAlert | Comments

(European Association for the Study of the Liver) According to new data presented today at the International Liver Congress, the United States could soon be faced with an epidemic of non-alcoholic fatty liver disease, one of the major contributing factors of chronic liver disease,...

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