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Regulus Therapeutics Initiates an Orphan and Rare Disease microRNA Therapeutic Effort in Brain Cancer

Mon, 12/12/2011 - 5:39am
Bio-Medicine.Org

LA JOLLA, Calif., Dec. 12, 2011 /PRNewswire/ -- Regulus Therapeutics Inc., a biopharmaceutical company leading the discovery and development of innovative medicines targeting microRNAs, today announced the initiation of a new discovery effort in microRNA therapeutics for the treatment of glioblastoma multiforme (GBM), the most common and aggressive brain tumor in humans. Regulus will apply its expertise in microRNA therapeutics to discover chemically modified oligonucleotide anti-miRs for testing at the Samsung Medical Center in preclinical models that mimic human brain cancer. Accelerate Brain Cancer Cure (ABC2), a non-profit organization dedicated to accelerating therapies for brain cancer patients, has awarded Regulus a grant to support the research.

 

"GBM is a devastating disease with limited treatment options," said Neil W. Gibson, Ph.D. Chief Scientific Officer of Regulus Therapeutics. "At Regulus, we have successfully targeted microRNAs in multiple disease settings and believe that targeting dysregulated microRNAs using chemically modified oligonucleotide anti-miRs provides a potential therapeutic approach for GBM."

 

"A major hurdle in the discovery and development of novel therapeutics for GBM has been the lack of relevant animal models," said Do Hyun Nam, Ph.D. Professor and Director of Institute for Refractory Cancer Research, Samsung Medical Center. "In our collaboration with Regulus, we will utilize a recently developed model in which tumors derived from human patients are transplanted into mice resulting in a model directly relevant to human disease."

 

"Regulus has an impressive track record of executing on innovation in the field of microRNA therapeutics," said Max Wallace, Chief Executive Officer, ABC2. "The combination of Regulus' expertise in microRNA therapeutics with Samsung's preclinical GBM models compelled us to support this pr

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