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Eutropics Pharmaceuticals signs $1.5M NCI/SBIR contract to develop companion diagnostic for guiding Multiple Myeloma treatments

Thu, 09/20/2012 - 12:34pm
Bio-Medicine.Org

CAMBRIDGE, Mass., Sept. 20, 2012 /PRNewswire/ -- Eutropics Pharmaceuticals has signed a $1.5M phase 2 contract with the National Cancer Institute Small Business Initiative Research (NCI-SBIR) to commercially develop  its proprietary diagnostic assay for personalized medicine approaches in Multiple Myeloma (MM) patient management. The award follows a highly successful phase 1 contract that demonstrated the commercial potential for the core technology called BH3 profiling.  Eutropics holds an exclusive license for this asset from equity partner, the Dana Farber Cancer Institute (DFCI).

(Logo: http://photos.prnewswire.com/prnh/20120920/NE78229LOGO )

The BH3 profiling technology provides a biomarker/diagnostic to help guide the use of several approved therapies for MM, as well as other cancer indications, and is being advanced as a companion test for experimental therapies currently in development. The biomarker provides a unique, functional understanding of cancer cells that indicates if they are capable of responding to certain treatments. This understanding will be particularly important in deciding when to use, or to avoid, certain therapies in newly diagnosed or relapsed/refractory MM patients. Such an approach will allow for the identification of the best treatment option for each individual patient.  Eutropics' approach is consistent with the July 2011 roadmap announcement made by the FDA calling for companion tests that will improve treatment efficacies by selecting appropriate use of targeted oncology therapies based on predictive molecular discriminators.

"Our physician colleagues, thought leaders in the area of treating multiple myeloma, have clearly indicated the need for new tools that will guide treatment. The NCI has confirmed our belief that this technology will provide such a tool and with this contract has requisitioned
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