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Green 532 nm Optically Pumped Semiconductor Lasers for Bioinstrumentation

Mon, 06/28/2010 - 7:13am

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Green 532 nm Optically Pumped Semiconductor Lasers for BioinstrumentationCoherent Inc. (Santa Clara, CA) (Nasdaq: COHR) has expanded its Sapphire family of compact CW visible lasers with 532 nm (green) lasers based on the company’s unique OPSL technology. Two models of the Sapphire 532 are being offered with a choice of either 200 or 300 mW output. As with other Sapphire lasers, these new 532 nm lasers provide a high quality TEM00 output beam characterized by low noise (0.25 % rms). Its combination of compact packaging (125 x 70 x 34 mm) and low power consumption translates into easier integration and lower cost of ownership for OEM instrument builders. Plus, these Sapphire 532 lasers have the same form, fit, and function as existing Sapphire LP series lasers at other wavelengths such as 460, 488, 514, 561, and 568 nm, simplifying incorporation of this new wavelength into existing instrument platforms.

Most traditional CW 532 nm lasers based on Nd:YVO4 crystals suffer from higher output noise because the intracavity doubling mechanism causes a well-known phenomenon called green noise. In contrast, the OPSL has a very short upper state lifetime which naturally eliminates green noise completely without additional measures, such as complex single longitudinal mode operation. Together with its high output power, this makes these Sapphire 532 lasers ideal for fast-throughput applications based on accurate measurements of relative fluorescence intensity.

Specific applications for Sapphire 532 lasers span several areas of bio-instrumentation that utilize fluorophores optimized for 532 nm excitation. These include DNA sequencing, flow cytometry, confocal microscopy, and high-throughput drug discovery.

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