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Setpoint Medical, a startup based in Boston, is developing a nerve stimulator designed to dampen the out-of-control immune system that triggers autoimmune diseases, such as inflammatory bowel disease and rheumatoid arthritis. The technology is based on a decade of research elucidating how the brain controls the immune system, particularly inflammation. The treatment has not yet been tested in patients, but based on animal research, scientists hope it will provide an alternative treatment that is more effective and have fewer side effects than existing drugs.

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