BANNOCKBURN, Ill., June 27, 2011 /PRNewswire/ -- Pinnacle Oncology LLC, a subsidiary of Pinnacle Biologics Inc. announced a wide ranging agreement with the University of Chicago for the acquisition of its technology and intellectual property rights for the development of a compound, amifostine, to prevent genomic instability caused by a variety of sources of ionizing radiation exposure including common Computer Tomography (CT) scans.
Amifostine was initially developed by the United States Army to protect military personnel from the toxic effects of radiation exposure in the event of a nuclear war. Animal studies revealed that amifostine is very effective in protecting against genomic instability and associated long term genomic damages resulting from radiation exposure, such as from CT scans and other diagnostic radiology and radiation oncology procedures that lead to DNA damages, chromosomal aberrations and gene mutations, all of which are associated with the cancer development processes.
"There are many potential uses for amifostine," said David Grdina, Professor of Radiation and Cellular Oncology at the University of Chicago and inventor of the technology behind the development of amifostine as a genomic stabilizing agent, "In addition to protecting against genomic instability, somatic mutagenesis and carcinogenesis, amifostine may also facilitate protection against germ line mutations. These exposures can come from a variety of sources including common diagnostic procedures, such as computer tomography (CT) scans and more generalized environmental exposures, as recently evidenced by the nuclear plant accident in Japan." At present, none of these potential uses have been approved by the FDA.
According to Viren Grover, Vice-Chairman at Pinnacle Biologics, "It is clear that CT scans have revolutionized diagnostic imaging and while they can provide great medical benefits, there is concern that diagnostic CT scans may be responsi