CHICAGO, June 5 /PRNewswire-USNewswire/ -- Scientists from the Barbara Ann Karmanos Cancer Institute in Detroit presented preliminary data that shows nitrogen-containing bisphosphonates, therapeutic agents used to promote bone health and inhibit resorption, may cause a slightly poorer survival rate in post-menopausal women with early stage breast cancer who take them for their anti-osteoporosis properties. The findings were announced today at the 2010 American Society of Clinical Oncology Annual Meeting.
Preclinical data suggests that bisphosphonates exhibit anti-tumor activity. Karmanos researchers, led by Zeina Nahleh, M.D., F.A.C.P., co-leader of the Breast Cancer Multidisciplinary Team and assistant professor of Internal Medicine at Karmanos and Wayne State University School of Medicine, conducted a two-year retrospective study that extracted data from the Metropolitan Detroit Cancer Surveillance System, a Surveillance, Epidemiology, and End Results registry.
A total of 696 patients 50 years and older with Stage I, II and III invasive breast cancer, diagnosed between 2000 and 2003, were included in the study. Ninety-seven women, or 14 percent of study participants, used nitrogen-containing bisphosphonates. The difference in overall survival between bisphosphonate users and non-users was not statistically significant at three years, with overall survival equating to 94 percent of bisphosphonate users and 88 percent of non-use