A versatile, straight hemostasis valve helps eliminate the backflow of fluid and accommodates a variety of devices up to 9.25 French, such as catheters, scopes, lasers, and guidewires. The valve's compact design features a large, easy-to-grip cap that facilitates smooth opening and closing of the valve. Its precision silicone closure gasket seals completely with or without a device in place. The valve has a standard ISO male luer with a rotating Spin-Lock collar and its body, cap, and collar are polycarbonate. Available bulk non-sterile or can be incorporated into a custom assembly.