Twisty-Flex circuits provide the noise reduction of twisted wire pairs or coax cable in a flexible circuit. The two layer design uses alternating conductors connected between layers by micro-vias. The result is a true twisted pair construction with a total thickness of less than 0.015 in. A wire pair can fit into a circuit less than 0.1 in. wide or integrate Twisty-Flex conductors with other signal or power conductors in a larger flex or rigid flex design.