The WebSeal System provides a high level of convenience for scientists working with 96 Well Micro Titer Plates. The 500 µl WebSeal Kit consists of a 96 well mid-depth polypropylene micro titer plate which is pre-inserted with 500 µl glass vials and includes the WebSeal silicon/PTFE sealing mat. The sealing mat provides for easy sealing of all 96 wells to eliminate cross contamination of the samples. A cutting tool is provided which allows individual tubes to be removed from the rack without breaking the seal. The sealing mats are available solid or pre-slit for easy penetration and they are dry heat autoclavable.