ComfortCoat is an advanced lubricious hydrophilic coating designed to enhance maneuverability of metal guidewires in minimally invasive procedures. For example, minimally invasive procedures are carried out to treat strokes, brain aneurysms, and other neurovascular diseases. Metal guidewires are more easily maneuvered within a patient's vasculature when the friction between the walls of the vessel and the intravascular guidewire is reduced by coating the device with a hydrophilic compound that becomes slippery after adsorbing waterfor example, when the coated device is exposed to water prior to insertion into a patient or into a patient's blood during use. However, it is important to note that, typically, hydrophilic coatings cannot be applied to metal guidewires because their adhesion to metal is poor, especially in the case of coiled guidewires. With ComfortCoat, adhesion to metal is not a problem; lubricity is maintained on the metal guidewire, which may enhance neurovascular maneuverability.